منابع مشابه
Epithelial Chloride Channel Development of lnhibitory Ligands
I N T R O D U C T I O N Chloride channels are present in the plasma membranes o f epithelia (Frizzell et al., 1981), nerve (Hamill et al., 1983), and muscle (Blatz and Magleby, 1985), as well as in intraceilular membranes such as Golgi apparatus (Glickman et al., Address reprint requests to Dr. Qais AI-Awqati, Depts. of Medicine and Physiology, College of Physicians and Surgeons, Columbia Unive...
متن کاملEpithelial chloride channel. Development of inhibitory ligands
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands that can aid us in further functional and eventually molecular characterization. To obtain such ligands, we prepared...
متن کاملDevelopment and validation of HTS assay for screening the calcium-activated chloride channel modulators in TMEM16A stably expressed CHO cells.
Calcium-activated chloride channels (CaCCs), for example TMEM16A, are widely expressed in a variety of tissues and are involved in many important physiological functions. We developed and validated an atomic absorption spectroscopy (AAS)-based detection system for high-throughput screening (HTS) of CaCC modulators. With this assay, Cl(-) flux from CHO cells stably transfected with TMEM16A is as...
متن کاملPotassium channels in health, disease & development of channel modulators.
Ion channels present in the plasma membrane and intracellular organelles of all cells, play an important role in maintaining cellular integrity, smooth muscle contraction, secretion of hormones and neurotransmitters. Among the ion channels, potassium channels (K(+)) are the most abundant having important role in cardiac repolarization, smooth muscle relaxation and insulin release. These are als...
متن کاملEffect of crude Venom of Odonthobuthus doriae scorpion in cell culture using ion channel modulators
Scorpion venom toxicity is one of the major medical concerns from old years, due to its influence on human activities and health. From many years ago a lot of researches established to examine different aspects of venom toxicity and its effects on different organs. During these years researchers are doing more specific studies on the cytotoxicity of scorpion venom. In Iran, Odonthobuthus doriae...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1995
ISSN: 0085-2538
DOI: 10.1038/ki.1995.380